Elimination of KATP channel in mouse islets results in elevated [U-C]glucose metabolism, glutaminolysis and pyruvate cycling but decreased GABA shunt
نویسندگان
چکیده
Changhong Li, Itzhak Nissim, Pan Chen, Carol Buettger, Habiba Najafi, Yevgeny Daikhin, Ilana Nissim, Heather W. Collins, Marc Yudkoff, Charles A. Stanley and Franz M. Matschinsky † Division of Endocrinology, ‡ Division of Child Development and Pediatric Rehabilitation, The Children’s Hospital of Philadelphia and § Diabetes Center and Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, USA Running Title: metabolic integration and insulin secretion Address correspondence to: Franz M. Matschinsky, Diabetes Center and Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, Phone: 215 898 1971, Fax: 215 59
منابع مشابه
An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
OBJECTIVE Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism. In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing and glucose-stimulated insulin secretion. METHODS To evaluate the role that the MPC plays in maintaining systemic glucose homeo...
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